I have good news and bad news:
Bad news: It turns out that currently, wine in Debian is faced with several bugs that make it unable to build from source: https://bugs.debian.org/cgi-bin/pkgreport.cgi?archive=no&pend-exc=pending-fixed&pend-exc=fixed&pend-exc=done&sev-inc=critical&sev-inc=grave&sev-inc=serious&repeatmerged=no&src=wine
Good news: Lukas managed to get a custom-built wine with wow64 support (so that one is emulated with box64) to run a 32bit windows game: minute: "bonus: here's fallout new vegas (32 bit intel) ru…" - Mastodon